An EC 1.1.1.* (oxidoreductase acting on donor CH-OH group, NAD(+) or NADP(+) acceptor) inhibitor which interferes with the action of 3beta-hydroxysteroid dehydrogenase (EC 1.1.1.210), a group of steroidogenic enzymes.
ChEBI ID: 50788
| Member | Definition | Class |
|---|---|---|
| trilostane | An epoxy steroid that is 3,17beta-dihydroxy-5alpha-androst-2-ene-2-carbonitrile in which the oxygen of the epoxy group is joined to the 4alpha and 5 alpha positions. | trilostane |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 81 (26.47) | 18.7374 |
| 1990's | 53 (17.32) | 18.2507 |
| 2000's | 83 (27.12) | 29.6817 |
| 2010's | 67 (21.90) | 24.3611 |
| 2020's | 22 (7.19) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 16 (4.88%) | 5.53% |
| Reviews | 16 (4.88%) | 6.00% |
| Case Studies | 37 (11.28%) | 4.05% |
| Observational | 1 (0.30%) | 0.25% |
| Other | 258 (78.66%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 23.4817 | 10 | 15 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 51.5007 | 2 | 3 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 11.1104 | 1 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 15.7654 | 4 | 8 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 8.1115 | 2 | 3 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 38.2722 | 6 | 9 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 61.6448 | 1 | 1 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 22.0703 | 2 | 4 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 37.2586 | 2 | 3 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 33.4889 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 43.6412 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 26.6616 | 2 | 4 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 18.5772 | 3 | 5 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 1.0962 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 17.5075 | 2 | 3 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 40.1140 | 2 | 4 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 21.6112 | 2 | 4 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 15.4323 | 2 | 3 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 14.3562 | 2 | 4 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 14.3562 | 2 | 4 |
| TDP1 protein | Homo sapiens (human) | Potency | 33.4983 | 1 | 1 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 76.9588 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 15.5168 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| ATP-binding cassette sub-family C member 3 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Canalicular multispecific organic anion transporter 1 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |
| Multidrug resistance-associated protein 4 | Homo sapiens (human) | IC50 | 133.0000 | 1 | 1 |